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1.
Rev Assoc Med Bras (1992) ; 68(1): 24-30, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-35239933

RESUMO

OBJECTIVE: The objective of this study was to determine the frequency of burnout, global, and by dimension, in resident physicians of Federal University of Piauí, and to identify possible factors associated with the presence of the syndrome. METHOD: This is a cross-sectional, observational, and descriptive study. Population: resident physicians in Federal University of Piauí's medical residency programs (136 individuals). The frequency of burnout was investigated using the Maslach Burnout Inventory. Sociodemographic variables were evaluated through a questionnaire and their associations with the presence of the syndrome were tested. RESULTS: A total of 67 (49.26%) residents answered the questionnaires. The burnout syndrome frequencies found were global=73.1%; EE=44.8%; DP=64.2%, and PA=47.8%. Statistically significant association was obtained between current year of residency and EE; between having children and PA; between current work routine and DP; and between the use of antidepressant/hypnotic medication and EE. Compared with residency programs, there was a difference in the EE dimension, which was higher among residents in internal medicine residents (88.9%) and pediatrics (83.3%). In the comparative analysis between global burnout levels and all variables evaluated, no associations were found. CONCLUSION: Burnout syndrome was found in the majority of participating residents. There was an association between sociodemographic variables and the presence of isolated burnout dimensions, but not between sociodemographic variables and global burnout.


Assuntos
Esgotamento Profissional , Internato e Residência , Médicos , Esgotamento Profissional/epidemiologia , Esgotamento Psicológico/epidemiologia , Criança , Estudos Transversais , Humanos , Inquéritos e Questionários , Universidades
2.
Rev. Assoc. Med. Bras. (1992) ; 68(1): 24-30, Jan. 2022. tab
Artigo em Inglês | LILACS | ID: biblio-1360715

RESUMO

SUMMARY OBJECTIVE: The objective of this study was to determine the frequency of burnout, global, and by dimension, in resident physicians of Federal University of Piauí, and to identify possible factors associated with the presence of the syndrome. METHOD: This is a cross-sectional, observational, and descriptive study. Population: resident physicians in Federal University of Piauí's medical residency programs (136 individuals). The frequency of burnout was investigated using the Maslach Burnout Inventory. Sociodemographic variables were evaluated through a questionnaire and their associations with the presence of the syndrome were tested. RESULTS: A total of 67 (49.26%) residents answered the questionnaires. The burnout syndrome frequencies found were global=73.1%; EE=44.8%; DP=64.2%, and PA=47.8%. Statistically significant association was obtained between current year of residency and EE; between having children and PA; between current work routine and DP; and between the use of antidepressant/hypnotic medication and EE. Compared with residency programs, there was a difference in the EE dimension, which was higher among residents in internal medicine residents (88.9%) and pediatrics (83.3%). In the comparative analysis between global burnout levels and all variables evaluated, no associations were found. CONCLUSION: Burnout syndrome was found in the majority of participating residents. There was an association between sociodemographic variables and the presence of isolated burnout dimensions, but not between sociodemographic variables and global burnout.


Assuntos
Humanos , Criança , Médicos , Esgotamento Profissional/epidemiologia , Internato e Residência , Universidades , Estudos Transversais , Inquéritos e Questionários , Esgotamento Psicológico
3.
Rev. Nutr. (Online) ; 35: e210052, 2022. tab
Artigo em Inglês | LILACS | ID: biblio-1394682

RESUMO

ABSTRACT Objective To evaluate the consumption of ultra-processed foods and associate it with anthropometric indicators in adolescents, adults, and the elderly. Methods Cross-sectional, domiciliary, population-based study, comprising adolescents aged 10-19 years, adults aged 20-59 years, and elderly people aged 60 or older, residents of the urban area of the city of Teresina, Piauí. Demographic, socioeconomic, lifestyle, food consumption, and anthropometric data were collected. The analysis of variance test was used along with the Bonferroni post-hoc test and crude and adjusted linear regression with a 95% confidence interval (95% CI). The level of significance adopted was 5%. Results There was no significant association between the consumption of ultra-processed foods and anthropometric variables in adults and the elderly. However, among adolescents, the results showed an inverse association, thus signaling a reduction in anthropometric indicators as the consumption of ultra-processed foods increases. Conclusion There was no association between the consumption of ultra-processed foods and anthropometric indicators in adults and the elderly; however, among adolescents, the results showed an inverse association, which encourages the development of new studies, especially longitudinal ones.


RESUMO Objetivo Avaliar o consumo de alimentos ultraprocessados e associá-lo a indicadores antropométricos em adolescentes, adultos e idosos Métodos Estudo transversal, domiciliar, de base populacional, compreendendo adolescentes de 10-19 anos, adultos de 2059 anos e idosos de 60 anos ou mais, residentes na zona urbana da cidade de Teresina, Piauí. Foram coletados dados demográficos, socioeconômicos, de estilo de vida, consumo alimentar e antropométrico. O teste de análise de variância foi utilizado juntamente com o teste post-hoc de Bonferroni e regressão linear bruta e ajustada com intervalo de confiança de 95% (IC95%). O nível de significância adotado foi de 5%. Resultados Não houve associação significativa entre o consumo de alimentos ultraprocessados e indicadores antropométricos em adultos e idosos, entretanto, entre os adolescentes, os resultados demonstraram uma associação inversa, sinalizando redução dos indicadores antropométricos à medida que se aumenta o consumo de ultraprocessados. Conclusão Não houve associação entre o consumo de alimentos ultraprocessados e indicadores antropométricos em adultos e idosos, entretanto, entre os adolescentes, os resultados demonstraram uma associação inversa, o que incentiva o desenvolvimento de novos estudos, especialmente, longitudinais.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Pesos e Medidas Corporais/métodos , /métodos , Brasil/etnologia , Idoso , Estudos Transversais , Adolescente , Adulto
4.
Artigo em Inglês | MEDLINE | ID: mdl-34912463

RESUMO

This study aimed to evaluate the effects of the treatment with bacuri seed butter (BB) on body weight, growth, body mass index, lipid profile, atherosclerotic indices, and liver function in dyslipidemic hamsters. Freshly weaned, male hamsters were divided into four groups: (1) normal group (NG)-maintained with standard chow (AIN-93G); (2) dyslipidemia group (DG)-maintained with hyperlipidemic chow (AIN-93G modified) throughout the follow-up period; (3) bacuri seed butter 25 mg/kg/day (BB-25); and (4) bacuri seed butter 50 mg/kg/day (BB-50). BB groups (25 and 50 mg/kg/day) were also maintained with hyperlipidemic chow throughout the follow-up period, and the treatment started after 21 days receiving a hyperlipidemic diet to induce hypercholesterolemia and maintained for 28 days. No significant differences in triglycerides and total cholesterol were observed for BB-25 and BB-50 groups when compared with NG and DG groups. On the contrary, BB-25 and BB-50 induced both increase of HDL-c (51.40 ± 1.69 and 51.00 ± 2.34, respectively) and decrease of LDL-c (103.80 ± 6.87 and 100.50 ± 3.95, respectively) when compared with DG (41.00 ± 2.94 and 132.70 ± 9.41, respectively). In addition, BB promoted a reduction in the risk of atherosclerotic disease by decreasing (p < 0.05) the atherogenic index, coronary artery risk index, and LDL/CT ratio (p < 0.05) and increasing HDL/CT ratio. On the contrary, no changes were observed in total cholesterol and triglyceride levels or in body weight, growth, body mass index, or liver function parameters. Thus, bacuri seed butter at doses of 25 and 50 mg/kg/day has positive repercussions on the lipid profile, more precisely on plasma HDL-c and LDL-c, and additionally promotes reduction in the risk of atherosclerosis in hamsters.

5.
Rev Saude Publica ; 55: 118, 2021.
Artigo em Inglês, Português | MEDLINE | ID: mdl-34932704

RESUMO

OBJECTIVE: To describe the methodological aspects of the Piauí home healthcare survey (ISAD-PI) and assess the relation between sampling plan, precision, and design effects, assuming that population health surveys are relevant instruments for health monitoring. METHODS: ISAD-PI was a population-based cross-sectional study that analyzed the living conditions and health status of the population residing in urban areas in the municipalities of Teresina and Picos, in Piauí. Sampling was carried out by conglomerates in two stages: Primary Sampling Units and households. To calculate the sample size, we considered the stratification of the population in both cities, according to the age of the individuals. We evaluated the "non-response" rate (NRR) and estimated the proportions according to sex and age, as well as the prevalence of social determinants of health in order to assess the compliance of the sampling plan. Analyses related to the precision according to the coefficient of proportion variation of the standard error (Cv-pˆ) and the design effect (deff). Cv-pˆ less than 20% and deff less than 1.5 were considered adequate. The total NRR of households was 38.2% in Teresina and 38.3% in Picos. We carried out twenty-four proportion estimates in relation to age and sex and 48 prevalence of social and health determinants estimates, totaling 72 estimates. Among them, 71 had Cv-pˆ less than 20% and 61 had deff less than or equal to 1.5. CONCLUSION: Data generated from the ISAD-PI may contribute to the assessment of health and morbidity conditions in the population. Furthermore, methodological aspects employed in this research may serve as a basis for studies carried out in other cities in Brazil.


Assuntos
Características da Família , Brasil , Estudos Transversais , Pesquisas sobre Atenção à Saúde , Inquéritos Epidemiológicos , Humanos
8.
Rev. saúde pública (Online) ; 55: 1-13, 2021. tab, graf
Artigo em Inglês, Português | LILACS, BBO - Odontologia | ID: biblio-1352196

RESUMO

ABSTRACT OBJECTIVE To describe the methodological aspects of the Piauí home healthcare survey (ISAD-PI) and assess the relation between sampling plan, precision, and design effects, assuming that population health surveys are relevant instruments for health monitoring. METHODS ISAD-PI was a population-based cross-sectional study that analyzed the living conditions and health status of the population residing in urban areas in the municipalities of Teresina and Picos, in Piauí. Sampling was carried out by conglomerates in two stages: Primary Sampling Units and households. To calculate the sample size, we considered the stratification of the population in both cities, according to the age of the individuals. We evaluated the "non-response" rate (NRR) and estimated the proportions according to sex and age, as well as the prevalence of social determinants of health in order to assess the compliance of the sampling plan. Analyses related to the precision according to the coefficient of proportion variation of the standard error (Cv-pˆ) and the design effect (deff). Cv-pˆ less than 20% and deff less than 1.5 were considered adequate. The total NRR of households was 38.2% in Teresina and 38.3% in Picos. We carried out twenty-four proportion estimates in relation to age and sex and 48 prevalence of social and health determinants estimates, totaling 72 estimates. Among them, 71 had Cv-pˆ less than 20% and 61 had deff less than or equal to 1.5. CONCLUSION Data generated from the ISAD-PI may contribute to the assessment of health and morbidity conditions in the population. Furthermore, methodological aspects employed in this research may serve as a basis for studies carried out in other cities in Brazil.


RESUMO OBJETIVO Descrever os aspectos metodológicos do Inquérito de Saúde Domiciliar no Piauí (ISAD-PI), bem como avaliar a conformidade do plano amostral em relação à precisão e aos efeitos do desenho, dado que os inquéritos populacionais de saúde constituem instrumentos importantes para o monitoramento da situação de saúde da população. MÉTODOS O ISAD-PI foi um estudo de base populacional, transversal, que analisou as condições de vida e situação de saúde da população residente nas áreas urbanas dos municípios de Teresina e Picos, no Piauí. A amostragem foi realizada por conglomerados, em dois estágios: Unidades Primárias de Amostragem e domicílios. Para o cálculo do tamanho da amostra, considerou-se a estratificação da população de ambas as cidades, de acordo com a idade dos indivíduos, para ambos os sexos. Para avaliação da conformidade do plano amostral, foi avaliada a taxa de "não-resposta" (TNR) e, além disso, as estimativas de proporções segundo sexo e idade, bem como as prevalências de determinantes sociais de saúde, que foram analisadas em relação à precisão por meio do coeficiente de variação da proporção do erro padrão (Cv-pˆ) e do efeito do delineamento (deff). Foram considerados adequados Cv-pˆ menores que 20%, e deff menores que 1,5. A TNR-Total dos domicílios foi de 38,2% em Teresina e de 38,3% em Picos. Foram realizadas 24 estimativas de proporção em relação à idade e ao sexo e 48 estimativas de prevalência de determinantes sociais e de saúde, totalizando 72 estimativas, das quais 71 apresentaram Cv-pˆ menor que 20% e 61 apresentaram deff menor ou igual a 1,5. CONCLUSÃO Dados gerados a partir do ISAD-PI poderão contribuir para a avaliação das condições de saúde e morbidade na população. Ademais, aspectos metodológicos empregados nesta pesquisa poderão servir de base para estudos realizados em outras cidades do Brasil.


Assuntos
Humanos , Características da Família , Brasil , Estudos Transversais , Inquéritos Epidemiológicos , Pesquisas sobre Atenção à Saúde
9.
Rev. saúde pública (Online) ; 55: 1-13, 2021. tab, graf
Artigo em Inglês, Português | LILACS, BBO - Odontologia | ID: biblio-1357421

RESUMO

ABSTRACT OBJECTIVE To describe the methodological aspects of the Piauí home healthcare survey (ISAD-PI) and assess the relation between sampling plan, precision, and design effects, assuming that population health surveys are relevant instruments for health monitoring. METHODS ISAD-PI was a population-based cross-sectional study that analyzed the living conditions and health status of the population residing in urban areas in the municipalities of Teresina and Picos, in Piauí. Sampling was carried out by conglomerates in two stages: Primary Sampling Units and households. To calculate the sample size, we considered the stratification of the population in both cities, according to the age of the individuals. We evaluated the "non-response" rate (NRR) and estimated the proportions according to sex and age, as well as the prevalence of social determinants of health in order to assess the compliance of the sampling plan. Analyses related to the precision according to the coefficient of proportion variation of the standard error (Cv-pˆ) and the design effect (deff). Cv-pˆ less than 20% and deff less than 1.5 were considered adequate. The total NRR of households was 38.2% in Teresina and 38.3% in Picos. We carried out twenty-four proportion estimates in relation to age and sex and 48 prevalence of social and health determinants estimates, totaling 72 estimates. Among them, 71 had Cv-pˆ less than 20% and 61 had deff less than or equal to 1.5. CONCLUSION Data generated from the ISAD-PI may contribute to the assessment of health and morbidity conditions in the population. Furthermore, methodological aspects employed in this research may serve as a basis for studies carried out in other cities in Brazil.


RESUMO OBJETIVO Descrever os aspectos metodológicos do Inquérito de Saúde Domiciliar no Piauí (ISAD-PI), bem como avaliar a conformidade do plano amostral em relação à precisão e aos efeitos do desenho, dado que os inquéritos populacionais de saúde constituem instrumentos importantes para o monitoramento da situação de saúde da população. MÉTODOS O ISAD-PI foi um estudo de base populacional, transversal, que analisou as condições de vida e situação de saúde da população residente nas áreas urbanas dos municípios de Teresina e Picos, no Piauí. A amostragem foi realizada por conglomerados, em dois estágios: Unidades Primárias de Amostragem e domicílios. Para o cálculo do tamanho da amostra, considerou-se a estratificação da população de ambas as cidades, de acordo com a idade dos indivíduos, para ambos os sexos. Para avaliação da conformidade do plano amostral, foi avaliada a taxa de "não-resposta" (TNR) e, além disso, as estimativas de proporções segundo sexo e idade, bem como as prevalências de determinantes sociais de saúde, que foram analisadas em relação à precisão por meio do coeficiente de variação da proporção do erro padrão (Cv-pˆ) e do efeito do delineamento (deff). Foram considerados adequados Cv-pˆ menores que 20%, e deff menores que 1,5. A TNR-Total dos domicílios foi de 38,2% em Teresina e de 38,3% em Picos. Foram realizadas 24 estimativas de proporção em relação à idade e ao sexo e 48 estimativas de prevalência de determinantes sociais e de saúde, totalizando 72 estimativas, das quais 71 apresentaram Cv-pˆ menor que 20% e 61 apresentaram deff menor ou igual a 1,5. CONCLUSÃO Dados gerados a partir do ISAD-PI poderão contribuir para a avaliação das condições de saúde e morbidade na população. Ademais, aspectos metodológicos empregados nesta pesquisa poderão servir de base para estudos realizados em outras cidades do Brasil.


Assuntos
Humanos , Características da Família , Brasil , Estudos Transversais , Inquéritos Epidemiológicos , Pesquisas sobre Atenção à Saúde
10.
Rev Assoc Med Bras (1992) ; 66(5): 630-636, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32638969

RESUMO

OBJECTIVE To estimate the prevalence of hypertension in adults and analyze its association with socioeconomic, demographic, and lifestyle risk factors. METHODS Home-based cross-sectional epidemiological study conducted with adults of both sexes living in the cities of Teresina and Picos (PI). The prevalence of hypertension was estimated by self-reported diagnosis. The associations between hypertension and the following variables were tested: age, gender, skin color, education, family income, marital status, alcohol and cigarette consumption, physical activity, and nutritional status. RESULTS A total of 1,057 adult individuals with a mean age of 38.6 ± 11.5 years participated in the study, of which 62.3% were female. The prevalence of hypertension in the population was 16.4%. In the crude analysis, a significant association was observed between the prevalence of hypertension and factors such as older age, lower education, single marital status, brown skin color, smoking, and overweight (p < 0.05). However, after adjustments, only the associations with older age, brown skin color, sedentary lifestyle and overweight remained significant. CONCLUSION Older age, brown skin color, sedentary lifestyle, and the presence of overweight or obesity were significantly associated with hypertension. Among the modifiable risk factors, a sedentary lifestyle and overweight stand out as important for the genesis of hypertension, subject to intervention measures.


Assuntos
Hipertensão , Adulto , Idoso , Cidades , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sobrepeso , Prevalência , Fatores de Risco , Fatores Socioeconômicos
11.
Demetra (Rio J.) ; 15(1): 44816, jan.- mar.2020. tab, ilus
Artigo em Português | LILACS | ID: biblio-1097198

RESUMO

Introdução: A linhaça dourada apresenta importantes quantidades de ácido αlinolênico, fibras solúveis e lignanas, podendo trazer benefícios para a saúde. Objetivo: Desenvolver paçoquinha adicionada de farinha de linhaça dourada (FLD) em diferentes proporções, bem como determinar sua composição centesimal e aceitação sensorial. Materiais e métodos: Foram elaboradas paçoquinhas com adição de 10%, 15% e 20% de FLD. A composição centesimal foi determinada e, após, foram aplicados testes de aceitação (escala hedônica). Os dados foram analisados através de teste de Kruskal Wallis e ANOVA, adotando-se nível de significância de 5%. Resultado: As paçoquinhas padrão e adicionadas de FLD não apresentaram diferença no teor de umidade (17,1 a 18,5%) e lipídeos (30,8 a 34,2%). Quanto ao teor de cinzas, apenas as formulações com 15 e 20% de FLD tiveram maior percentual, 1,94% e 2,03%, respectivamente. O teor de proteínas foi significativamente menor nas formulações com adição de linhaça (15,4 a 18,5%) e a quantidade de fibras alimentares aumentou nas formulações com FLD. Em relação à análise sensorial, as paçoquinhas adicionadas de FLD obtiveram boa aceitabilidade, não sendo observadas diferenças significativas com relação aos atributos avaliados em comparação com a paçoquinha padrão. Conclusão: Os dados obtidos permitiram verificar que é possível a substituição parcial do amendoim em paçoquinhas por farinha de linhaça dourada, pois os novos produtos apresentaram características sensoriais que agradaram aos consumidores em todos os atributos avaliados, além de apresentarem valor nutricional superior no que se refere ao incremento de fibras e teor de minerais. (AU)


Introduction: Golden flaxseed has important amounts of α-linolenic acid, soluble fibers and lignans, which can bring benefits to health. Objective: To prepare peanut candy added with golden flaxseed flour (GFF) in different proportions and determine its proximate composition and sensory acceptance. Materials and methods: Peanut candies were prepared with the addition of 10%, 15% and 20% of GFF. The proximate composition was determined and then acceptance tests (hedonic scale) were applied. Data were analyzed using the Kruskal Wallis test and ANOVA, adopting a significance level of 5%. Result: Regular peanut candy and a preparation added with GFF showed no difference in moisture (17.1 to 18.5%) and lipid (30.8 to 34.2%) content. As for ash content, only formulations with 15 and 20% of GFF had the highest percentage, 1.94% and 2.03%, respectively. The protein content was significantly lower (15.4 to 18.5%) and the amount of dietary fiber increased in formulations with GFF. In relation to sensory analysis, the candies added with GFF obtained good acceptability, with no significant differences regarding the attributes evaluated in comparison with the regular peanut candy. Conclusion: The data obtained allowed us to see that it is possible to partially replace peanuts with golden flaxseed flour in the preparation of candies, as the new products presented sensory characteristics that pleased consumers in all the evaluated attributes, in addition to superior nutritional value with regard to increased fiber and mineral content. (AU)


Assuntos
Linho , Alimento Funcional , Ácidos Graxos , Alimentos, Dieta e Nutrição
12.
Rev Assoc Med Bras (1992) ; 66(5): 630-636, 2020. tab, graf
Artigo em Inglês | Sec. Est. Saúde SP, LILACS | ID: biblio-1136262

RESUMO

SUMMARY OBJECTIVE To estimate the prevalence of hypertension in adults and analyze its association with socioeconomic, demographic, and lifestyle risk factors. METHODS Home-based cross-sectional epidemiological study conducted with adults of both sexes living in the cities of Teresina and Picos (PI). The prevalence of hypertension was estimated by self-reported diagnosis. The associations between hypertension and the following variables were tested: age, gender, skin color, education, family income, marital status, alcohol and cigarette consumption, physical activity, and nutritional status. RESULTS A total of 1,057 adult individuals with a mean age of 38.6 ± 11.5 years participated in the study, of which 62.3% were female. The prevalence of hypertension in the population was 16.4%. In the crude analysis, a significant association was observed between the prevalence of hypertension and factors such as older age, lower education, single marital status, brown skin color, smoking, and overweight (p < 0.05). However, after adjustments, only the associations with older age, brown skin color, sedentary lifestyle and overweight remained significant. CONCLUSION Older age, brown skin color, sedentary lifestyle, and the presence of overweight or obesity were significantly associated with hypertension. Among the modifiable risk factors, a sedentary lifestyle and overweight stand out as important for the genesis of hypertension, subject to intervention measures.


RESUMO OBJETIVO Estimar a prevalência de hipertensão arterial em adultos e analisar sua associação com fatores de risco socioeconômicos, demográficos e de estilo de vida. MÉTODOS Estudo epidemiológico transversal, de base domiciliar, realizado com adultos de ambos os sexos residentes nas cidades de Teresina e Picos (PI). A prevalência de hipertensão arterial foi estimada por meio de diagnóstico autorreferido. Foram testadas as associações entre a hipertensão arterial e as variáveis: idade, sexo, cor da pele, escolaridade, renda familiar, situação conjugal, consumo de álcool e cigarro, prática de atividade física e estado nutricional. RESULTADOS Participaram do estudo 1.057 indivíduos adultos com média de idade de 38,6 ± 11,5 anos, sendo 62,3% do sexo feminino. A prevalência de hipertensão arterial na população foi de 16,4%. Na análise bruta, observou-se associação significativa entre a prevalência de hipertensão e fatores como maior idade, menor escolaridade, estado civil solteiro, cor da pele parda, tabagismo e excesso de peso (p<0,05). Entretanto, após ajustes, apenas as associações com a maior idade, cor da pele parda, estilo de vida sedentário e excesso de peso mantiveram-se significativas. CONCLUSÃO A idade mais avançada, cor da pele parda, sedentarismo e a presença de sobrepeso ou obesidade apresentaram-se significativamente associados à hipertensão. Dentre os fatores de risco modificáveis, destaca-se o sedentarismo e o excesso de peso como importantes para a gênese de hipertensão e passíveis de medidas de intervenção.


Assuntos
Humanos , Masculino , Feminino , Adulto , Idoso , Hipertensão , Fatores Socioeconômicos , Prevalência , Estudos Transversais , Fatores de Risco , Cidades , Sobrepeso , Pessoa de Meia-Idade
13.
Nutrients ; 11(2)2019 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-30781884

RESUMO

This work assessed the effects of a 28-day treatment with lycopene-rich extract (LRE) from red guava fruit (Psidium guajava L.) on the lipid profile and oxidative stress in an experimental model of dyslipidemia. Male hamsters (116.5 ± 2.16 g) were fed with the AIN 93G diet containing casein (20%), coconut fat (13.5%) and cholesterol (0.1%). The animals were divided into four groups: normolipidemic control (standard feed; NC, n = 7); hypercholesterolemic control (HC, n = 7); LRE 25 mg/kg/day (LRE-25, n = 7) and LRE 50 mg/kg/day (LRE-50, n = 9). After treatment, plasma concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL) cholesterol (LDL-c), high-density lipoprotein (HDL) cholesterol (HDL-c), malondialdehyde (MDA-p) and myeloperoxidase (MPO), as well as erythrocytic superoxide dismutase (SOD-e) and the atherogenic index, were determined. Malondialdehyde (MDA-h), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD-h) levels were assessed. Feed intake (FI) and weight gain (WG) were also determined. The LRE-25 group presented significantly lower TG levels and atherogenic index than did the HC group (p < 0.05). Both LRE-25 and LRE-50 groups presented lower levels of MDA-p and MPO than did the HC group (p < 0.05). LRE demonstrated a promising effect against dyslipidemia and oxidative stress.


Assuntos
Dislipidemias/induzido quimicamente , Licopeno/química , Estresse Oxidativo/efeitos dos fármacos , Extratos Vegetais/farmacologia , Psidium , Triglicerídeos/sangue , Animais , Biomarcadores/sangue , Cricetinae , Gorduras na Dieta/administração & dosagem , Gorduras na Dieta/efeitos adversos , Dislipidemias/tratamento farmacológico , Masculino , Extratos Vegetais/química
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